Pathophysiology
Cardiovascular
- Capillary permeability is increased
- Loss of intravascular proteins and fluids into interstitial space
- Peripheral and splenic vasoconstriction occurs
- Decreased myocardial contractility
- All of these result in hypotension and end organ hypo perfusion
- Broncho-constriction from inflammatory mediators
- Adult respiratory distress syndrome
- Basal metabolic rate increases about 3x its original
- Down-regulation of main response affects both cell-mediated and humoral pathways